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Velocity mapping of the aortic flow at 9.4 T in healthy mice and mice with induced heart failure using time-resolved three-dimensional phase-contrast MRI (4D PC MRI).

Philipp Rene Bovenkamp, Tobias Brix, Florian Lindemann, Richard Holtmeier, Desiree Abdurrachim, Michael T. Kuhlmann, Gustav J. Strijkers, Jörg Stypmann, Klaus H. Hinrichs, Verena Hoerr
Magnetic Resonance Materials in Physics, Biology and Medicine , page 1-13 - 2014
Objectives

In this study, we established and validated a time-resolved three-dimensional phase-contrast magnetic resonance imaging method (4D PC MRI) on a 9.4 T small-animal MRI system. Herein we present the feasibility of 4D PC MRI in terms of qualitative and quantitative flow pattern analysis in mice with transverse aortic constriction (TAC).

Materials and methods

4D PC FLASH images of a flow phantom and mouse heart were acquired at 9.4 T using a four-point phase-encoding scheme. The method was compared with slice-selective PC FLASH and ultrasound using Bland–Altman analysis. Advanced 3D streamlines were visualized utilizing Voreen volume-rendering software.

Results

In vitro, 4D PC MRI flow profiles showed the transition between laminar and turbulent flow with increasing velocities. In vivo, 4D PC MRI data of the ascending aorta and the pulmonary artery were confirmed by ultrasound, resulting in linear regressions of R 2 > 0.93. Magnitude- and direction-encoded streamlines differed substantially pre- and post-TAC surgery.

Conclusions

4D PC MRI is a feasible tool for in vivo velocity measurements on high-field small-animal scanners. Similar to clinical measurement, this method provides a complete spatially and temporally resolved dataset of the murine cardiovascular blood flow and allows for three-dimensional flow pattern analysis.

Images and movies

 

BibTex references

@article{BBLHAKSSHH14,
  author = {Bovenkamp, Philipp Rene and Brix, Tobias and Lindemann, Florian and Holtmeier, Richard and Abdurrachim, Desiree and Kuhlmann, Michael T. and Strijkers, Gustav J. and Stypmann, J{\"o}rg and Hinrichs, Klaus H. and Hoerr, Verena},
  title = {Velocity mapping of the aortic flow at 9.4 T in healthy mice and mice with induced heart failure using time-resolved three-dimensional phase-contrast MRI (4D PC MRI).},
  journal = {Magnetic Resonance Materials in Physics, Biology and Medicine },
  pages = {1--13},
  year = {2014},
  keywords = {Small-animal imaging; Blood flow velocity; MRI; Cardiovascular system},
  url = {http://viscg.uni-muenster.de/publications/2014/BBLHAKSSHH14},
}

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